Question: Does adjusting Nvidia GPU settings impact performance?

I've done a fair bit of googling and haven't come up with a single site/page/forum thread that discusses optimizing my GPU for Painter.  I have a background in gaming so probably more familiar with changing all of the settings than others w/o a gaming background.  Has anyone tweaked their 3d settings, or even the simple "performance vs quality" setting to see if it affects performance in those brushes that utilize the GPU in Painter?